supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Both melatonin antagonists, prazosin and luzindole, exhibited no effect per se and reversed both responses to melatonin.”
“Our data suggest that SK‐Mel 28 cells probably possess high affinity binding sites to melatonin and, in addition, MT3 low affinity binding sites, because N‐acetylserotonin was as effective as the native hormone, and prazosin effectively blocked the actions of melatonin.”
Melatonin biological activity and binding sites in human melanoma cells“However, when melatonin was added with exogenous selective Mel1b antagonist (4‐phenyl‐2‐propionamideotetralin) and selective Mel1c antagonist ( prazosin ), the level of Pit‐1 mRNA and the GH secretion decreased.”
Melatonin Receptor Mel1b‐ and Mel1c‐mediated Green Light Induced the Secretion of Growth Hormone in Anterior Pituitary of Chicks“The antinociceptive effect of melatonin was antagonized by luzindole, 4-P-PDOT, and prazosin in the spinal cord.”
“The anticonvulsant effect of melatonin was blocked by bicuculline, a GABA(A) receptor antagonist, and luzindole, an ML(1) receptor antagonist, while prazosin , an ML(2) receptor antagonist, enhanced the anticonvulsant actions of melatonin in this seizure model.”
“ Prazosin reduced the NE‐mediated melatonin release only in SDR but not in TGR pinealocytes.”
“In the presence both of prazosin and of melatonin , the norepinephrine-induced production of inositol phosphate was abolished in smooth muscle cells from spontaneously hypertensive rats.”
“These findings suggest that prazosin may be a potent antagonist at a unique, non-alpha-adrenergic, high-affinity binding site for melatonin.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback