Possible Interaction: Melatonin and Potassium Chloride

“In the part of contraction recording of colonic smooth muscle, melatonin inhibited the fortified spontaneous contraction induced by WAS, and decreased the amplitude of spontaneous contraction stimulated by Ach and KCl after WAS treatment.”

“Bath application of KCl elicited fluorescence increases that were reduced by melatonin.”

“ Melatonin (10(-5)-10(-3) M) and the melatonergic agonist N-acetylserotonin (10(-5) M) inhibited contraction to KCl.”

“The melatonergic antagonist luzindole (2 x 10(-6) M) did not inhibit the melatonin (10(-3) M)-induced inhibition of KCl contraction in the rat aorta.”

“ Melatonin caused a dose-dependent relaxation of precontracted (30 mM KCl ) pulmonary artery and pulmonary vein.”

“ Melatonin caused a dose‐dependent relaxation of precontracted (30 mM KCl ) vascular smooth muscle.”

“ Melatonin (10(-4)-10(-3) M) inhibited contractile response to 5-hydroxytryptamine (5-HT) and KCl in rat isolated aorta.”

“In rabbit basilar arteries, melatonin (10(-5)-10(-3) M) and nifedipine (10(-10)-10(-8) M) inhibited the responses to KCl and 5-hydroxytryptamine.”

“ Melatonin or nifedipine inhibited the Ca2+-responses in a Ca2+-free medium containing KCl (40 mM) or 5-HT (10(-5) M).”

“These results suggest that melatonin and nifedipine inhibit the same Ca2+ channels activated by KCl.”

“However, pre-treatment with melatonin decreases contractile responses induced by phenylephrine, acetylcholine, bethanechol and KCl in a dose-dependent manner.”

“ Melatonin (10-7 M) also blocked contraction induced by high KCl ([KCl]ECF; 35 mM, 70 mM, 105 mM, and 140 mM) and EFS.”