“ Melatonin dose‐dependently lowered piroxicam and indomethacin‐induced gastric damage with more than 90% inhibition at a dose of 60 mg/kg BW.”
“Oral administration of piroxicam to rats caused a threefold increase in the tissue levels of hydroxyl radical generation, a change significantly attenuated by melatonin.”
“The results of the present studies also reveal that melatonin may influence the expression of Cu‐Zn SOD, catalase, cyclooxygenase as well as alpha‐actinin whose levels were found to be altered, following piroxicam treatment.”