Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Melatonin and Piroxicam

supplement:

Melatonin

Research Papers that Mention the Interaction

Melatonin dose‐dependently lowered piroxicam and indomethacin‐induced gastric damage with more than 90% inhibition at a dose of 60 mg/kg BW.
Oral administration of piroxicam to rats caused a threefold increase in the tissue levels of hydroxyl radical generation, a change significantly attenuated by melatonin.
The results of the present studies also reveal that melatonin may influence the expression of Cu‐Zn SOD, catalase, cyclooxygenase as well as alpha‐actinin whose levels were found to be altered, following piroxicam treatment.
Journal of pineal research  •  2004  |  View Paper