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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Melatonin
drug:
Phenobarbital
Research Papers that Mention the Interaction
“We found that melatonin significantly potentiated the anticonvulsant efficacy of phenobarbital , but did not exert anticonvulsant effects on its own.”
Melatonin potentiates the anticonvulsant action of phenobarbital in neonatal rats“Administering melatonin to the phenobarbital-treated rats significantly reduced (P < 0.01) the lipid peroxidation levels (23.5%), labelling index (38.2%) and rate of DNA synthesis (29.0%), and increased the cell cycle time.”
“Furthermore, melatonin displayed powerful protection against the toxic effect of phenobarbital.”
“ Melatonin at the subconvulsive dose of 25 mg/kg potentiated the anticonvulsive activity of carbamazepine and phenobarbital (ED50 values were significantly decreased from 12.1 to 8.3 and from 18.9 to 11.8 mg/kg, respectively).”
“Pretreatment with phenobarbital decreased the effectiveness of MIH to prolong hexobarbital sleeping times while pretreatment with SKF 525A added to the potentiating effect of MIH.”
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