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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“In the median eminence of intact hamsters, the accumulation of DA after pargyline was reduced to 22% of controls by melatonin injections; in ovariectomized hamsters, the accumulation of DA was reduced to 9% of controls by melatonin injections.”
“The accumulation of norepinephrine after pargyline was significantly reduced by melatonin administration only in ovariectomized hamsters.”
Effects of daily afternoon melatonin administration on monoamine accumulation in median eminence and striatum of ovariectomized hamsters receiving pargyline.“The monoamine oxidase inhibitor pargyline (100 μM) caused a sixfold increase in melatonin release, and the serotonin precursor 5‐hydroxy‐L‐tryptophan (100 μM) caused a 70‐fold increase.”
“Two commonly used monoamine oxidase inhibitors, tranylcypromine and pargyline , produced dose-dependent decreases in the activity of serotonin-containing neurons in the dorsal raphe in awake, freely-moving cats.”
“ Pargyline injection increased both NAT activity and melatonin content, an effect nullified by conjunct propranolol injection.”
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