Possible Interaction: Melatonin and Oxytocin

“The lack of effects of melatonin on basal and angiotensin II-stimulated oxytocin secretion argues against the possibility that melatonin exerts an overall modulatory role on oxytocin secretion in humans.”

“Finally, melatonin synergizes with oxytocin to promote delivery of the fetus.”

“iv) the propensity for parturition to occur at night may relate to the synergism between the nocturnal increase in melatonin and oxytocin.”

“RESULTS Our results reveal that me atonin si gnificantly inhibits oxy tocin re ceptor mRNA expression primarily via the melatonin 2 receptor.”

“ Melatonin also stimulated oxytocin output.”

“The influence of melatonin on the vasopressinergic and oxytocinergic neurones activity is mediated partly through a cAMP-dependent mechanism.”

“ Melatonin significantly inhibited basal and histrelin-induced release of OT in vitro, and displayed no significant influence on OT release in the presence of GnRH or its antagonist.”

“The results show, for the first time, that highly selective NK-1 receptor agonist, i.e., [… (Tyr(6),D-Phe(7),D-His(9))-Substance P (6-11) - sendide - diminishes significantly OT secretion; the latter peptide was also found to … at the concentration of 10(-7) M/L. Melatonin ….”

“In … of melatonin on … to oxytocin (0.5 x 10(-11), 1 x 10(-11), and 2 x 10(-11)M) amounting to 48, 77, and 59.5% … contraction as well as 62, 19.9, and 47% reduction in the area under the curve (AUC) of uterine contractions, respectively.”

“ Melatonin diminished basal release of AVP; it also significantly inhibited the substance P-stimulated secretion of AVP and OT.”

“The present results show that the stimulatory effect of substance P on basal release of AVP and OT from rat hypothalamo-neurohypophysial system in vitro is sensitive to inhibitory influence of melatonin.”

“The present results confirm previous reports as to the inhibitory effect of melatonin on both vasopressin and oxytocin secretion from the hypothalamo-neurohypophysial complex in vitro.”

“The present results show that NKA stimulated basal vasopressin and oxytocin release from the isolated hypothalamo-neurohypophysial system, when used at the concentration of 10(-7) M/L. Melatonin diminished basal release of the neurohypophysial hormones; it also significantly inhibited the NKA-stimulated secretion of vasopressin and oxytocin.”