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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Melatonin
drug:
Olanzapine
Research Papers that Mention the Interaction
“Similarly, replacement therapy with melatonin reduces weight gain secondary to the use of anti psychotics such as olanzapine (Raskind et al., 2007).”
Strategies to control antipsychotic-induced weight gain“In the SCN, olanzapine phosphorylated the GSK‐3β, a regulator of clock activity, which melatonin prevented.”
Olanzapine‐induced early cardiovascular effects are mediated by the biological clock and prevented by melatonin“ Olanzapine treatment reduced nocturnal plasma melatonin by 55% (p<0.001), which was restored to control levels by olanzapine+melatonin.”
“The effect was more pronounced for the combination of olanzapine with melatonin and metformin.”
Combination of Olanzapine Pamoate with Melatonin and Metformin: Quantitative Changes in Rat Adipose Tissue
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