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Last Updated: 2 years ago

Possible Interaction: Melatonin and Norepinephrine

supplement:

Melatonin

Research Papers that Mention the Interaction

In young men and women, melatonin influences vascular reactivity and reduces blood pressure and norepinephrine levels.
Journal of pineal research  •  2000  |  View Paper
In young individuals melatonin administration reduces circulating norepinephrine.
Clinical endocrinology  •  2000  |  View Paper
Melatonin administration significantly decreased mean PI of internal carotid artery (P < 0.02), systolic and diastolic blood pressure (P < 0.01), and norepinephrine levels evaluated after 5 min of standing position (P < 0.02).
The American journal of physiology  •  1998  |  View Paper
Since NA stimulates the production and secretion of melatonin , these results are consistent with a sustained increase in noradrenergic activity within the pineal, during 21 days of treatment with an effective NA uptake inhibitor.
Psychological medicine  •  1992  |  View Paper
In particular it is suggested that NE is largely functionally opposed to 5HT, ACH, MT , and possibly DA in AD.
International journal of molecular sciences  •  2021  |  View Paper
Melatonin inhibits the 70mM K(+)-induced norepinephrine release at a similar effective concentration range in PC12 cells.
Brain Research  •  2014  |  View Paper
The molecular mechanisms of this process have … characterized as the following: nighttime release of noradrenaline in the mammalian pineal gland (which activates β-adrenergic receptors to stimulate adenylate cyclase activity … elevate cAMP) up-regulates the activity of 5-HT N-acetyltransferase and subsequently increases melatonin levels in … circadian fashion.
The American journal of psychiatry  •  2006  |  View Paper
Interestingly, the effects of noradrenaline , the major neurotransmitter in the sympathetic nerve fibers, displays opposite effects on the melatonin biosynthesis in birds and mammals: it stimulates the melatonin biosynthesis in the mammalian pineal organ, but inhibits the melatonin formation in the chicken.
Annals of the New York Academy of Sciences  •  1994  |  View Paper
Studies have shown that oral administration of melatonin decreases blood pressure, vascular reactivity, and norepinephrine levels [5].
International journal of cardiology  •  2011  |  View Paper
Melatonin and related compounds increase sleep by suppressing the activity of the neurons in the brain's circadian clock, and NE influences the synthesis of melatonin.
Biochemical pharmacology  •  2010  |  View Paper
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