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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Melatonin
drug:
Nitroprusside
Research Papers that Mention the Interaction
“Continuous perfusion … the antioxidants melatonin , trolox, 21-[4-(2,6-di-1-pyrrolidinyl-4-pyrrimidinyl)-1-piperazinyl]-pregna-1,4,9(11)-triene-3,20-dione(Z)-2-butenedioate (U74389G), and diethyldithiocarbamate prevented the effect of sodium nitroprusside on MOR desensitization, but they did not themselves alter the desensitization.”
Enhancement of μ-Opioid Receptor Desensitization by Nitric Oxide in Rat Locus Coeruleus Neurons: Involvement of Reactive Oxygen Species“In the presence of melatonin , the concentration-response curve to SNP , but not 8-Br-cGMP, was shifted to the right.”
“Out of the five substances tested (prostaglandin E(2); 5-hydroxytryptamine; bethanechol; histamine; sodium nitroprusside) melatonin inhibited the effect of prostaglandin E(2) (PGE(2)) and sodium nitroprusside (SNP).”
“ Melatonin significantly inhibited the accumulation of cyclic guanosine monophosphate (cGMP) levels induced by both L‐arginine and sodium nitroprusside (SNP).”
“ Melatonin also inhibited coronary artery relaxation induced by sodium nitroprusside (10(-9)-10(-5) M) but not by isoproterenol (10(-9)-10(-5) M).”
“Unexpectedly, the sympathetic reactivity to nitroprusside , evaluated by the increases in NE and EPI, was markedly enhanced after melatonin treatment in both WKY and SHR.”
“We describe in the present report: …), 2) a dose‐dependent inhibition of melatonin … SNP and SIN‐1, but not by 8‐Br‐cGMP in both bovine and rat pineal cell cultures, which … synthase (NOS) (EC 1.14.23.‐) in the intact bovine pineal gland and in cultured bovine pinealocytes.”
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