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Last Updated: 2 months ago

Possible Interaction: Melatonin and Nitric Oxide

supplement:

Melatonin

Research Papers that Mention the Interaction

After treatment with melatonin the concentration of nitric oxide metabolites in gastric juice in both groups decreased and were 8.21 +/- 1.83 microM in patients with Epigastric Pain Syndrome and 6.93 +/- 1.61 microM in patients with Postprandial Disorders Syndrome.
After treatment with melatonin the concentration of nitric oxide metabolites in gastric juice in both groups decreased--in patients with Epigastric Pain Syndrome as well as in patients with Postprandial Disorders Syndrome.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego  •  2007  |  View Paper
Melatonin can stimulate the release of proinflammatory cytokines and other mediators, … different conditions, it can suppress inflammation-promoting processes such as NO release, activation of cyclooxygenase-2, inflammasome NLRP3, gasdermin D, toll-like receptor-4 and …, and cytokine release by SASP (senescence-associated secretory phenotype), and amyloid-β toxicity.
International journal of molecular sciences  •  2019  |  View Paper
Melatonin markedly inhibited hydrogen peroxide (H2O2)‐stimulated cytotoxicity, iNOS, and COX‐2 protein and mRNA expression, as well as the downstream products, NO and PGE2.
Journal of pineal research  •  2012  |  View Paper
Melatonin affords protection to the BBB in hypoxic conditions by suppressing the production of vascular endothelial growth factor and nitric oxide which are known to increase vascular permeability.
Current medicinal chemistry  •  2008  |  View Paper
NO production increases only after administration of melatonin.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society  •  2008  |  View Paper
Melatonin can, via its scavenging and antioxidant nature, improve endothelial function with increased availability of nitric oxide exerting vasodilatory and hypotensive effects.
Journal of pineal research  •  2007  |  View Paper
Antioxidants, such as melatonin , vitamin C, and vitamin E, probably play important roles in reducing or eliminating the oxidant damage produced by NO.
Annals of the New York Academy of Sciences  •  2005  |  View Paper
Additionally, melatonin reportedly reacts with nitric oxide (NO), the peroxynitrite anion (ONOO-) and/or peroxynitrous acid (ONOOH) to detoxify them.
Advances in experimental medicine and biology  •  2003  |  View Paper
Antioxidants, such as melatonin , vitamin C, and vitamin E, probably play an important acute and chronic role in reducing or eliminating the oxidant damage produced by NO.
Experimental Gerontology  •  1998  |  View Paper
The damage to the pituitary could also impair responses to stress and infection, and the release of NO during infection could be responsible for the degenerative changes in the pineal and diminished release of melatonin , an antioxident, and consequently, an antiaging hormone, that occur with age.
Experimental Gerontology  •  1997  |  View Paper
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