Possible Interaction: Melatonin and Nifedipine

“ Nifedipine , an L-type calcium channel blocker, reduces melatonin synthesis in rat pineal glands in vitro.”

“ Melatonin (1 micromol/L and 0.1 nmol/L) increased the content of met-Enk of lymphocytes in 2- and 11-month-old mice, respectively (P<0.01), which was blocked by nifedipine (1 micromol/L).”

“Meanwhile, the decrease of thymocyte proliferation in AA rats had a marked relation with the decrease of Met-Enk level in these thymocytes, melatonin (10(-10) or 10(-6) mol l(-1)) could markedly enhance the Met-Enk level, which were blocked by nifedipine , a Ca2+ channel antagonist.”

“Finally, nifedipine , an effective antagonist of l‐type voltage‐sensitive calcium channels, prevented the effects of melatonin on KCl‐evoked [3H]5‐HT release during the light but not the dark phase.”

“The calcium channel antagonist nifedipine inhibited LH release from cultured pituitary to a similar degree as melatonin and prevented the inhibitory effect of melatonin on LH release.”

“Calcium channel antagonist nifedipine inhibited LH release from cultured pituitary to a similar degree as did melatonin and prevented the inhibitory effect of melatonin on LH release.”

“In the absence of endothelium, verapamil but not nifedipine further inhibited the melatonin relaxation.”

“ Nifedipine and verapamil partly inhibited the melatonin relaxation on the 5-HT response.”

“Nitrendipine and nifedipine also prevent the nocturnal rise in melatonin output, while Bay K 8644 increases it, suggesting a role for voltage-dependent Ca2+ channels in regulating melatonin output.”

“This Ca2+ dependent, nifedipine insensitive contraction was markedly inhibited or abolished by melatonin at 10(-5) and 10(-4) M. These results demonstrated that melatonin had a generally greater inhibitory effect on the response to 5-HT than those to NE, AT-1 and potassium in vascular smooth muscles.”