Possible Interaction: Melatonin and Nicotine

“ Melatonin , a mitochondrially targeted antioxidant, reduced the ROS level, and blocked autophagy activation and the morphologic structural changes induced by nicotine.”

“ Melatonin also counteracts nicotine effects by reshaping the overall cytoskeleton architecture and abolishing invasive membrane protrusion.”

“It is concluded that melatonin has a protective effect on the heart and lungs against the harmful effect of nicotine.”

“ Melatonin … nicotine on the previous parameters either partially or completely, where melatonin restored complete blood count, improved lipid profile, mended lipid peroxidation and antioxidant parameters in … heart and lungs, ameliorated DNA fragmentation percentage in the heart, and protected both heart and lung tissue against the harmful effect of nicotine.”

“We assessed whether treatment with fermented rooibos (RF), unfermented rooibos (RUF) and melatonin (Mel), a well-documented antioxidant included for comparison, could counter the harmful vascular and pro-oxidant effects of nicotine.”

“Also, the increased numbers of alveolar macrophages and mast cells resulting from exposure to NT were decreased following MEL treatment.”

“Application of MEL ameliorated the histological and biochemical damage caused by NT.”

“Results indicated that there is significant variation … activity and body temperature depressant effects of nicotine … melatonin proficient C3H/Ibg strain with maximal sensitivity occurring during the latter third of the light period of … minimal sensitivity taking place during the last third of the dark phase of the light cycle.”

“The melatonin deficient strains did not exhibit diurnal differences in sensitivity to the effects of nicotine suggesting a potential role for melatonin in modulating the effects of nicotine.”

“Based on these findings, melatonin is able to minimize the negative effects of nicotine by blocking the activation of ERK and the other signalling pathways in which this enzyme is involved.”

“Again, melatonin treatment reduced both nitrotyrosine reactivity and tissue damage associated with nicotine administration.”

“The results suggest that chronic nicotine treatment slightly suppresses the melatonin production but does not alter the daily rhythm of pineal melatonin in mice maintained on a light-dark cycle.”

“Exogenous melatonin shifted the concentration-response curves for nicotine to the left, mimicking the effect of darkness.”