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Last Updated: 2 years ago

Possible Interaction: Melatonin and Ng-Nitroarginine Methyl Ester

Research Papers that Mention the Interaction

While the antinociceptive effect of melatonin was increased by l-arginine, SNAP, and sildenafil, it was significantly reduced by l-NAME and glibenclamide in both phases of the formalin test, with no relation to the sedative effects of melatonin evaluated by the inclined plane test.
Behavioural pharmacology  •  2020  |  View Paper
Synergistic anticonvulsant effect on aminophylline seizures was seen when L-NAME was combined with melatonin.
Nitric oxide : biology and chemistry  •  2014  |  View Paper
Further, L-NAME (5 mg/kg) pretreatment with sub-effective dose of melatonin (2.5 mg/kg, ip) significantly potentiated melatonin's protective effect which was significant as compared to their individual effect per se.
Indian journal of experimental biology  •  2011  |  View Paper
The synthesis was also less when the melatonin administration was combined with the melatonin 2-preferring receptor antagonist luzindole (24%), the non-selective nitric oxide synthase inhibitor L-NAME (18%) and the neuronal nitric oxide synthase inhibitor N-PLA (21%).
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society  •  2011  |  View Paper
Melatonin diminishes myocardial fibrosis in rats exposed to continuous light and NG-nitro-L-arginine-methyl ester (L-NAME) treatment and reduces production of endothelium-derived constricting factors in L-NAME-induced hypertension.
Journal of hypertension  •  2010  |  View Paper
Our results suggest that L-NAME treatment enhances melatonin production in the pineal gland, potentially by decreasing an inhibitory effect of NO on melatonin production in the pineal gland.
Hypertension Research  •  2009  |  View Paper
L-NAME (1 mg/kg) reversed the anticonvulsant property of the combination of melatonin (10 mg/kg) plus morphine (0.5 mg/kg).
Moreover, L-NAME (5 mg/kg) blocked the enhancing effect of melatonin (10 mg/kg) on proconvulsant activity of morphine (60 mg/kg).
Epilepsy Research  •  2007  |  View Paper
Pretreatment with L-NAME (30 mg/kg) and N(G)-nitro-L-arginine (L-NNA, 10 mg/kg) inhibited the anticonvulsant property of melatonin (40 and 80 mg/kg) and melatonin 40 mg/kg, respectively.
Epilepsy Research  •  2006  |  View Paper
Melatonin administration to L-NAME rats significantly reduced the MDA values resulting from I/R. We also demonstrated that I/R, and especially L-NAME+I/R, lead to structural changes in the kidney and that melatonin attenuates these changes.
These results suggest that melatonin reduces BP and I/R injury in NOS inhibited rats by L-NAME.
Acta histochemica  •  2006  |  View Paper
Melatonin administration (10 mg/kg) to L-NAME treated rats significantly reduced BP and infarct size.
Scandinavian cardiovascular journal : SCJ  •  2006  |  View Paper
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