Possible Interaction: Melatonin and Neuroprotective Agents

“Due to the relationships between mitochondrial damage, aging and neurodegenerative diseases, the effects of melatonin here described further support its antiaging and neuroprotective properties.”

“While more experimental studies should be conducted to further explore … to document any synergistic or additive protection from combining melatonin with … other neuroprotectants , interested clinical scientists should consider planning phase II and III studies to confirm … melatonin as an acute stroke treatment or a preventive measure for stroke patients.”

“The effects of melatonin on the differentiation of NSCs have been reported, and these effects may be responsible for its neuroprotective properties.”

“In our TBI experimental model, TRPM2 channels were involved in Ca2+ entry-induced neuronal death, and the negative modulation of the activity of this channel by melatonin pretreatment may account for the neuroprotective activity of TRPM2 channels against oxidative stress, apoptosis, and Ca2+ entry.”

“This may contribute to their symptoms, since melatonin is an effective chronobiotic and antioxidant with neuroprotective properties.”

“These results suggest that melatonin exerts a neuroprotective action.”

“These results provide new hormonal mechanism regulating mitochondrial homeostasis and may explain, at least in part, the anti-aging and neuroprotective properties of melatonin.”

“ Melatonin exerts potent free radical scavenging, antioxidant, and neuroprotective properties.”

“ Melatonin release is a more sensitive parameter than NAT activity to the action of neuroactive agents , suggesting that melatonin synthesis can be regulated by more than one enzymatic step in Rana perezi.”

“ Melatonin is the primary sleep-regulating hormone and a potent antioxidant with neuroprotective roles.”