Possible Interaction: Melatonin and Naltrexone

“This preliminary study was carried out to evaluate whether the association of NTX may further enhance the lymphocytosis induced by the neuroimmunotherapy with IL-2 plus MLT.”

“Subcutaneous (1 mg/kg) or intrathecal (0.5–50 μg) treatment with naltrexone , but not vehicle, significantly diminished the antiallodynic effect induced by oral (150 mg/kg) or intrathecal (100 μg) administration of melatonin.”

“Concomitant administration of naltrexone and melatonin significantly reduced the immunoenhancing effect of melatonin across all naltrexone doses.”

“In both tumor-bearing or healthy mice, the effect of melatonin is negated by naltrexone , indicating the involvement of MIO15.”

“We found that besides anti‐IL4 monoclonal antibody (mAb), the opioid antagonist naltrexone also neutralized the colony stimulating activity and part of the hematopoietic protection exerted by melatonin.”

“Subcutaneous melatonin injection (1.4 mg/Kg) had no significant effect on serum PRL levels, but decreased by 29% and 26% respectively the inhibitory effect potency of naltrexone (2.5 mg/Kg) and nalmefene (2 mg/Kg) on PRL secretion after simultaneous injections.”

“Splenic PFC number in chickens was diminished by both melatonin and naltrexone injections, whereas in mice it was increased by melatonin, and naltrexone antagonized that effect.”

“Moreover, the action of melatonin was blocked by naltrexone (p < 0.005), indicating the involvement of melatonin-induced-immuno-opioids in the development of the lymphomas.”

“These activities of TRH or melatonin are antagonized by the opioid receptor blocker naltrexone.”

“These remarkable immunopharmacologic effects of melatonin were abolished by naltrexone , suggesting an involvement of the endogenous opioid system.”