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“In the presence of naloxone , the GH response to MEL was completely abolished, whereas naloxone did not modify the pyridostigmine-induced GH increase.”
Metabolism: clinical and experimental • 1998 | View Paper
“Although melatonin is not regulated as a drug, it may interact with benzodiazepines, be antagonized by naloxone and flumazenil, and interact with melatonin receptors in the central nervous system and elsewhere in the body.”
Journal of endocrinological investigation • 1988 | View Paper
“Administration of both l-arginine and naloxone , at doses which produced no effect on their own, partially reversed antihyperalgesic effect of melatonin.”
Yao xue xue bao = Acta pharmaceutica Sinica • 2000 | View Paper
“An intraventricular treatment with melatonin , which did not affect the basal LH concentration by itself, significantly suppressed the effect of naloxone.”
“While the antinociceptive effect of melatonin was sensitive to reversal by naloxone (2 mg/kg), other CNS depressant profile resembled the effects of benzodiazepines.”
“Subcutaneous melatonin injection (1.4 mg/Kg) had no effect on LH secretion, but caused an inhibition effect (84%) on LH release induced by naloxone (2.4 mg/Kg).”