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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The percent of partial responses achieved in patients treated with morphine alone was significantly lower than that observed in patients concomitantly treated with MLT (1/16 vs. 4/14, p<0.05).”
Abrogation of the Negative Influence of Opioids on IL–2 Immunotherapy of Renal Cell Cancer by Melatonin“Co-administration of melatonin and low-dose morphine had better analgesia effects in the murine models of pain and led to a lower NLRP3 inflammasome activity in brain tissues.”
“In mice, coadministration of melatonin with morphine ameliorated morphine-induced behavioral sensitization, analgesic tolerance and mtDNA content reduction.”
“Since melatonin may behave as a mixed opioid receptor agonist‐antagonist, it is doubtful that a physician simply could potentiate the analgesic efficacy of narcotics such as morphine by coadministering melatonin.”
“ Melatonin also increases the anti‐nociceptive actions of opioids, such as morphine , and reverses their tolerance through regulating several cellular signaling pathways.”
“ Melatonin decreases morphine consumption in different pathologies.”
“Therefore, it is reasonable to believe that the combination of melatonin with morphine could reduce morphine‐induced tolerance and hyperalgesia, which may result from anti‐inflammatory and antioxidant properties of melatonin.”
“Furthermore, there was a significant inverse correlation between changes in endogenous melatonin levels and morphine consumption.”
“Also, the anxiolytic effect of melatonin and clonidine resulted in reduced postoperative morphine consumption by more than 30%.”
“However, following the treatment of morphine with melatonin , the MPAE% was reduced only about 30%, comparing with those that received saline treatment as control.”
“These increased levels of expression of PKCγ and NR1 were significantly inhibited by co-administration of morphine with melatonin.”
“This morphine-induced mechanical and thermal hyperalgesia were greatly attenuated by co-administration of morphine with melatonin.”
Melatonin prevents morphine-induced hyperalgesia and tolerance in rats: role of protein kinase C and N-methyl-D-aspartate receptors“By measuring PKC activity and cAMP levels, the upregulated PKC activity and cAMP levels induced by morphine were significantly inhibited by melatonin.”
“This effect of melatonin after morphine administration may mediated by inhibiting PKC activity and cAMP upregulation.”
“These results suggest that MEL increases the expression of β-EP in ARH of morphine-dependent mice, which may partly contribute to the action of MEL to inhibit the development of morphine dependence.”
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