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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Melatonin
drug:
Methysergide
Research Papers that Mention the Interaction
“In contrast, concommitant injections of methysergide (6.25 mg/kg) and melatonin attenuated testicular regression and loss of body weight.”
“ Methysergide , which has a very low affinity for inhibition of 2‐[125I]‐iodomelatonin binding, probably inhibits the effects of melatonin by blocking serotonergic neurotransmission.”
Effects of Melatonin Agonists and Antagonists on Reproduction and Body Weight in the Siberian Hamster“Neither drug had any significant effect on the duration of immobility under normal conditions, but methysergide significantly reduced the prolongation of immobility duration produced by injections of melatonin.”
“The stimulatory effect of serotonin and the inhibitory effect of melatonin on iodine incorporation by thyroid follicular cells are both inhibited by the serotonin antagonists methysergid and cyphroheptadine.”
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