Possible Interaction: Melatonin and Methylselenocysteine

“ Melatonin diminished the extent of MSC apoptosis in oxidative stress conditions by regulating the levels of apoptosis‐associated proteins, such as BCL‐2, BAX, PARP‐1, and caspase‐3, in a PrPC‐dependent manner.”

“Treatment with melatonin enhanced MSC proliferation and self‐renewal via upregulation of cellular prion protein (PrPC) expression.”

“In this respect melatonin emerges a novel and potential modulator of MSC lineage commitment and adipogenic differentiation.”

“In this scenario, melatonin seems to regulate signaling pathways that drive commitment and differentiation of MSC into osteogenic, chondrogenic, adipogenic, or myogenic lineages.”

“Collectively, MT will be a promising agent for enhancing MSC activities and the regenerative capacity via the regulation of reactive oxygen species (ROS) generation and the release of immune factors in regenerative medicine.”

“The findings suggest that melatonin may be an effective protective agent against H2O2-induced oxidative stress and apoptosis in MSC.”

“Moreover, a better understanding of the enhancement of MSC growth and osteogenic differentiation resulting from the combination of ECM and melatonin could improve the design of graft substitutes for skeletal tissue engineering.”

“MSCs were pretreated with melatonin (1, 10, and 100 nM, respectively) for 30 min, followed by exposure to 400 µM H2O2 and melatonin together for 12 h. The present study reports that melatonin pretreatment significantly attenuated H2O2‐induced MSC apoptosis in a dose‐dependent manner.”