Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: a year ago

Possible Interaction: Melatonin and Methotrexate



Research Papers that Mention the Interaction

Mel (… MTX were significantly lower than that of DDP or MTX alone (all P<0.05).CI values of cells exposed to 1 mmol/L Mel ….1, 0.5, 1, 2, and 4 mmol/L MTX were 0.88, 0.88 ,0.83, 0.78, and 0.81, respectively.
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae  •  2015  |  View Paper
These findings reveal that melatonin has the potential to diminish the negative effects of MTX on memory and neurogenesis.
Biochemical pharmacology  •  2019  |  View Paper
ResultPretreatment with melatonin had a dose-dependent protective effect on methotrexate (MTX)-induced alterations in small intestinal morphology.
Digestive Diseases and Sciences  •  2012  |  View Paper
Melatonin pretreatment reduced MTX induced oxidative stress, alteration in the activity of antioxidant enzymes as well as elevation in myeloperoxidase activity.
Pretreatment with melatonin reduced MTX induced renal damage both histologically and biochemically as revealed by normal plasma creatinine levels.
The results suggest that melatonin has the potential to reduce MTX induced oxidative stress, neutrophil infiltration as well as renal damage.
Cell biochemistry and function  •  2010  |  View Paper
In conclusion, the present study suggests that melatonin may be of therapeutic benefit when used with MTX.
Journal of pineal research  •  2003  |  View Paper