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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Melatonin
drug:
Methotrexate
Research Papers that Mention the Interaction
“… Mel (… MTX were significantly lower than that of DDP or MTX alone (all P<0.05).CI values of cells exposed to 1 mmol/L Mel ….1, 0.5, 1, 2, and 4 mmol/L MTX were 0.88, 0.88 ,0.83, 0.78, and 0.81, respectively.”
Effects of melatonin combined with Cis-platinum or methotrexate on the proliferation of osteosarcoma cell line SaOS-2.“These findings reveal that melatonin has the potential to diminish the negative effects of MTX on memory and neurogenesis.”
Melatonin protects against methotrexate‐induced memory deficit and hippocampal neurogenesis impairment in a rat model“ResultPretreatment with melatonin had a dose-dependent protective effect on methotrexate (MTX)-induced alterations in small intestinal morphology.”
“ Melatonin pretreatment reduced MTX induced oxidative stress, alteration in the activity of antioxidant enzymes as well as elevation in myeloperoxidase activity.”
“Pretreatment with melatonin reduced MTX induced renal damage both histologically and biochemically as revealed by normal plasma creatinine levels.”
“The results suggest that melatonin has the potential to reduce MTX induced oxidative stress, neutrophil infiltration as well as renal damage.”
“In conclusion, the present study suggests that melatonin may be of therapeutic benefit when used with MTX.”
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