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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Melatonin and Methotrexate



Research Papers that Mention the Interaction

These findings reveal that melatonin has the potential to diminish the negative effects of MTX on memory and neurogenesis.
Biochemical pharmacology  •  2019  |  View Paper
When the cells were treated with Mel combined with DDP or MTX , the apoptotic cells were more than that of DDP or Mel alone(P<0.05).
Mel (… MTX were significantly lower than that of DDP or MTX alone (all P<0.05).CI values of cells exposed to 1 mmol/L Mel ….1, 0.5, 1, 2, and 4 mmol/L MTX were 0.88, 0.88 ,0.83, 0.78, and 0.81, respectively.
  •  2015  |  View Paper
ResultPretreatment with melatonin had a dose-dependent protective effect on methotrexate (MTX)-induced alterations in small intestinal morphology.
Digestive Diseases and Sciences  •  2012  |  View Paper
Melatonin pretreatment reduced MTX induced oxidative stress, alteration in the activity of antioxidant enzymes as well as elevation in myeloperoxidase activity.
Pretreatment with melatonin reduced MTX induced renal damage both histologically and biochemically as revealed by normal plasma creatinine levels.
The results suggest that melatonin has the potential to reduce MTX induced oxidative stress, neutrophil infiltration as well as renal damage.
Cell biochemistry and function  •  2010  |  View Paper
In conclusion, the present study suggests that melatonin may be of therapeutic benefit when used with MTX.
Journal of pineal research  •  2003  |  View Paper