Possible Interaction: Melatonin and Methionine

“Extending our previous observations, we have shown on HaCat cells that melatonin , at ~10−9 M concentration, transiently raises not only the expression of the neuronal nitric oxide synthase (nNOS) mRNA, but also the nNOS protein synthesis and the nitric oxide oxidation products, nitrite and nitrate.”

“ Melatonin at concentrations of 10−7 and 10−6 M reverses the delayed process and increases apoptosis activity in neutrophils in patients with SAP.”

“There was no statistically significant effect of Me on PG production when Me was administered at concentrations between 10–4 and 10–8 M. However, at 10–3 M Me significantly suppressed PG output of granulosa cells.”

“In an ovarian adenocarcinoma cell line (BG‐1), we find that melatonin at concentrations of 10−9‐10−7 M caused a 20–25% reduction in cell number.”

“Assessment of the inhibitory effect of 10−9–10−6 M melatonin on AA‐induced TxB2 production indicated that melatonin activity was greater at 01:30 h as compared to late night.”

“Inhibition by 10−6 M melatonin of AA‐induced PRP aggregation was observed only in samples taken at 01:30 hr.”

“Our results show that treatment with 10−5 M melatonin significantly decreased the ROS level and increased the GPx, SOD, and CAT activities of sex-sorted bull sperm, which inhibited PS externalization and MDA levels, and improved Δψm, acrosomal integrity, and fertilization ability.”

“In this study, we found that melatonin supplementation at 10−8 and 10−9 M in M16 significantly reduced two‐cell block of mouse embryos.”

“ Melatonin with a concentration of 10−7 M significantly enhanced the rates of nuclear maturation, cumulus cells expansion, cleavage, and blastocyst.”

“ Melatonin also lowered the serum levels of Asp, Ser, Met , and Leu (p < 0.05), but increased those of Glu and Cys (p < 0.05).”

“Renal angiotensin-converting enzyme 2 protein levels in the M and CR + M groups were also significantly increased by melatonin therapy.”