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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Melatonin
drug:
Methamphetamine
Research Papers that Mention the Interaction
“ Melatonin , via its antiradical mechanisms, also reduces the toxicity of noxious prescription drugs and of methamphetamine , a drug of abuse.”
Melatonin as an antioxidant: under promises but over delivers“Nanomolar concentrations of melatonin have been shown to protect against the inflammation caused by METH and to prevent the decrease in neurogenesis caused by METH in progenitor cells obtained from adult rat hippocampal tissue.”
“ Melatonin also promotes autophagy through inhibiting methamphetamine toxicity to protect against neuronal cell death in AD brain.”
“Furthermore, we demonstrated that pretreatment with melatonin attenuated the overexpression of ER stress-related genes and the cleavages of caspase-12 and -3 caused by METH exposure.”
“These findings suggest the protective effects of melatonin against ER stress and apoptosis caused by METH and other harmful agents.”
“The results showed that pretreatment with 100nM melatonin could prevent the TNFα overexpression caused by methamphetamine exposure.”
“ Melatonin reversed the toxic effects of METH by restoring cell viability and inhibiting the increase in mitochondrial Fis1 levels and the mitochondrial translocation of Drp1 and Bax.”
“The results show that melatonin significantly decreases the iNOS protein expression and TNF-α mRNA levels caused by METH.”
“An induction of calpain expression and activity but a reduction of calpain inhibitor (calpastatin) protein levels were observed in SH‐SY5Y cells treated with METH but these effects were diminished by melatonin.”
“ Melatonin reversed the toxic effect of METH by inducing cell viability.”
“This work demonstrates a novel role for melatonin as a neuroprotective agent against METH.”
“We found that a pretreatment with melatonin enhances mTOR activity and 4EBP1 phosphorylation and protects against the formation of LC3‐II in SK‐N‐SH cells exposed to METH.”
“Pretreatment of 10 mg/kg melatonin prior to treating with METH was able to reduce an increase in the levels of NG2 and activation in astrocyte and microglia.”
The induction of Neuron-Glial2 (NG2) expressing cells in methamphetamine toxicity-induced neuroinflammation in rat brain are averted by melatonin
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