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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
Research Papers that Mention the Interaction
“Daily administration of melatonin and zinc improved the impaired lipid profile and decreased the level of MAU; the addition of this treatment regimen in combination with metformin improved the tissue responses to this oral hypoglycemic agent.”
“The administration of antioxidants such as melatonin and zinc may improve tissue responses to insulin and increase the efficacy of drugs, e.g. metformin , which act through this pathway.”
Effects of melatonin and zinc on lipid profile and renal function in type 2 diabetic patients poorly controlled with metformin“Melatonin administration was able to protect the ileum remarkably, while the combination of melatonin and metformin was less effective.”
“MEL decreased proliferation in mammary cancer cells; positive correlations between histological grade and Ki67 expressions were found after single administration of both MF and MEL.”
“OBJECTIVE Numerous reports showed inhibition of carcinogenesis after metformin (MF) and melatonin ( MEL ) administration.”
Metformin and melatonin improve histopathological outcome of NMU-induced mammary tumors in rats.“Long-term administration of metformin and melatonin exerts antioxidant properties in liver, especially in combination.”
“ Metformin and melatonin combined reversed the effects of NMU on oxidative stress.”
“Importantly, the combination of melatonin and metformin had synergistic actions to modify progression of metabolic dysfunction in CDO rats through improved adiposity, circadian activity, insulin sensitivity, and islet cell failure.”
“ Metformin and AICAR both reduced (p < 0.001 and p < 0.01 respectively) the amplitude of the circadian rhythm of melatonin secretion independently of insulin secretion.”
“injection of two activators of AMPK, metformin and AICAR, affected the circadian rhythm of melatonin in ewes that were housed in constant darkness.”
“Here we demonstrated that a combination of metformin and melatonin significantly inhibits growth of transplanted tumors in mice.”
“Conclusion The combination of melatonin with metformin can protect mice spermatogenesis against ionizing radiation more effectively compared to the single forms of these drugs.”
“Interestingly, the melatonin and metformin combination reversed the reduced number of sperms rather than single drug administration.”
Radioprotective effect of a combination of melatonin and metformin on mice spermatogenesis: A histological study“The association with melatonin, metformin, or the combination of melatonin with metformin attenuated the olanzapine-induced adipose deposit tissue growth.”
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