Possible Interaction: Melatonin and Leptin

“Concurrent supplementation of melatonin , a natural anti-oxidant, to these rats prevents the effects of leptin.”

“The BC risk related to obesity may be reduced by melatonin which decrease body fat mass, inhibits the enhanced aromatase expression in obese women, increases adiponectin secretion, counteracts the oncogenic effects of elevated concentrations of leptin ; and decreases blood glucose levels and insulin resistance.”

“Moreover, melatonin down‐regulated several markers of terminal adipocyte differentiation, including leptin (30%), lipoprotein lipase (LPL, 41%), adiponectin (51%), and adipocyte protein 2 (αP2, 45%).”

“Based on this evidence, it is proposed that GLUT-4, TNF-alpha, EFAs, daf-genes, melatonin and leptin interact with each other in ways which may have relevance to the development or abrogation of insulin resistance, obesity, NIDDM, complications due to NIDDM, longevity and ageing.”

“In the present study, it was observed that melatonin positively regulated the level of leptin in female mouse and pig.”

“In addition, the miR‐7 expression is up‐regulated by leptin … JAK/STAT3 signaling pathway, and the in vivo intracerebroventricular injection of leptin increases miR‐7 expression by 80.0% (P = ….0044) in porcine pineal glands and reduces melatonin levels by 57.1% (P = ….0060) compared with the controls.”

“ Melatonin reverses leptin methylation and expression and decreases inflammation and chronic liver steatosis not via apoptosis or histone deacetylation (HDAC).”

“In early-pregnant ewes (day 30 and 45), leptin decreased melatonin plasma concentrations (P < 0.05), but at day 60, leptin stimulated melatonin plasma concentrations at low (P < 0.01) and high doses (P < 0.05), with no effects in ewes after 105 d of gestation.”

“In conclusion, the adverse effects of leptin on sperm can be prevented by concurrent melatonin administration.”

“The augmented levels of circulating leptin and adiponectin seen in high-fat fed rats were counteracted by melatonin as was the augmented body weight: melatonin significantly attenuated a body weight increase in high-fat fed rats without affecting chow or water consumption.”