“Furthermore, Melatonin significantly enhances the anti-tumor effect of Lapatinib in an HCC1954 xenograft model.”
“Importantly, Melatonin also increases the sensitivity of HCC1954 LapR cells to Lapatinib.”
“Mechanistically, Melatonin enhances the cytotoxic effects of Lapatinib through promoting excessive EnR stress-induced unfolded protein response (UPR) and ROS overaccumulation.”