Possible Interaction: Melatonin and Iron, Dietary

“ MEL administration prevented the changes induced by Fe and rHuEPO and had no adverse side effects.”

“Vitamin E and melatonin can prevent the majority of metal-mediated ( iron , copper, cadmium) damage both in vitro systems and in metal-loaded animals.”

“Pretreatment of human 28SC cells for 24 h before irradiation with 2 mM melatonin reduced the level of X-ray induced double-strand breaks by ∼50%, of abasic clustered damages about 40%, and of Fe ion-induced double-strand breaks (41% reduction) and abasic clusters (34% reduction).”

“ Melatonin has been reported to reduce cytokine production and, in dialysis patients, to prevent oxidative stress resulting from iron and erythropoietin treatment.”

“ Melatonin also prevents poisoning by such elements like chromium (III) and (VI), iron and copper, through levelling toxic actions of these ions on organism.”

“Collectively, melatonin plays a protective role in iron overload‐induced osteogenic differentiation dysfunction and senescence through blocking ROS accumulation and p53/ERK/p38 activation.”

“Because melatonin (MLT) is a broad spectrum antioxidant, we investigated the ability of MLT to control iron , its binding proteins, and the oxidative damage induced by ADR.”

“ Melatonin and its precursor, N‐acetylserotonin (NAS), have been shown in in vivo and in vitro studies to inhibit iron‐ and lipopolysaccharide (LPS)‐induced lipid peroxidation in rats and mice.”

“Instead, when the cells were treated with melatonin or trolox and then exposed to iron ions and 7 mT SMF, the level of lipid peroxidation was significantly reduced.”

“Supporting an antioxidant function, melatonin (100 microM) significantly decreased redox active iron , heme-oxygenase (HO-1) induction and 8-hydroxyguanosine (8-OHG) following NMDA (50-100 microM) insult.”