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Last Updated: 2 years ago

Possible Interaction: Melatonin and Irinotecan

supplement:

Melatonin

Research Papers that Mention the Interaction

Our results indicate that melatonin can modulate the genotoxic activity of irinotecan and DNA repair efficacy in human cancer cells in vitro.
The combination of melatonin at concentrations of 50 μM with increasing doses of irinotecan (7.5, 15, 30, and 60 μM) resulted in an increase in the amount of DNA damage in A549 and HT29 cancer cells, but was not effective in inducing DNA damage in healthy human lymphocytes.
Drug and chemical toxicology  •  2013  |  View Paper
The synergistic effects of the combined treatment were evident in many other cancer cell lines, and melatonin was also highly effective in inducing cancer death when combined with other cancer drugs, including cisplatin, 5-fluorouracil, irinotecan , and sorafenib.
Experimental & molecular medicine  •  2021  |  View Paper