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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Melatonin
drug:
Interleukin-10
Research Papers that Mention the Interaction
“Further investigation in vitro revealed that melatonin administration increased FoxP3 and IL-10 expression in CD4+ T cells from MG patients and enhanced the suppressive function of Tregs.”
Melatonin exerts immunoregulatory effects by balancing peripheral effector and regulatory T helper cells in myasthenia gravis“ Melatonin may increase T helper 17 (Th17) cell differentiation (Kuklina 2014), antigen presentation to T cells, and production of cytokines interleukin-10 , interleukin-1, and TNF-alpha (Pioli et al. 1993), resulting in downstream T cell proliferation.”
“In contrast, IL-10 did not alter these parameters but was able to reduce the prooxidant effects yielded by serotonin, adenosine, melatonin , or TNFα, in part by restoring the antioxidant enzymes activities.”
“It has been shown that plasma melatonin and possibly cortisol mainly regulate the diurnal variation of interferon F and interleukin 10 (IL-10), respectively.”
“In vitro doses of melatonin significantly increased PBMC proliferation (p<0.05) and decreased IL-10 production in culture supernatants (p<0.05).”
“These data support the notion that physiologic doses of melatonin increase lymphocyte proliferation possibly due to decreases in production of the inhibitory cytokine IL-10.”
“Moreover, melatonin significantly inhibited NF-κB expression and upregulated IL-10 expression, and it reversed the blast-induced high expression of caspase-3 and Bax and the low expression of Bcl-2.”
Melatonin pretreatment alleviates blast-induced oxidative stress in the hypothalamic-pituitary-gonadal axis by activating the Nrf2/HO-1 signaling pathway.“Furthermore, MT combined with MSCs markedly reduced serum levels of circulating allospecific IgG and IgM, as well as decreased the levels of pro-inflammatory IFN-γ, TNF-α, IL-1β, IL-6, IL-17A, and MCP-1, but increased the level of IL-10 in the recipients.”
“Conversely, IL10 induced a significant increase in melatonin production associated with increased AA-NAT/P-AA-NAT expressions.”
“In BM cells, LPS and IL10 induced an increase in melatonin levels associated with the increased expressions of P-AA-NAT and ASMT.”
“…,melatonin supplementation inverted the SD-induced the decline of antioxidant enzyme … (T-AOC and CAT etc) and anti-inflammatory cytokines ( IL-10 and IFN-γ) and the increase of oxidative product MDA, pro-inflammatory cytokines (IL-6 and TNF-α), p-P65 and p-IκB proteins in the SI.”
“But melatonin administration increased the IL-10 levels in comparison with TBI + VEH group (p < 0.001).”
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