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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Melatonin
drug:
Hypochlorite
Research Papers that Mention the Interaction
“ Melatonin prevents HOCl –mediated MPO heme destruction through multiple pathways.”
Melatonin Prevents Myeloperoxidase Heme Destruction and the Generation of Free Iron Mediated by Self-Generated Hypochlorous Acid“Here we demonstrate that HOCl alters metaphase‐II mouse oocyte microtubules and chromosomal (CH) alignment which can be prevented by melatonin.”
Melatonin prevents hypochlorous acid‐induced alterations in microtubule and chromosomal structure in metaphase‐II mouse oocytes“The well-known antioxidant melatonin interacted with the oxidant and significantly protected cells during HOCl exposure, diminishing its cytotoxic effects and reducing protein carbonyl generation.”
“ Melatonin could also prevent the oxidation of 5-thio-2-nitrobenzoic acid by HOCl.”
“ Melatonin also inhibits myeloperoxidase, the enzyme that catalyzes the oxidation of chloride to HOCl.”
Oxidation of melatonin by taurine chloramine“It has been found that melatonin reacts rapidly with hypochlorous acid in phosphate-buffered, ethanol-water solutions to produce 2-hydroxymelatonin.”
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