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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Melatonin
Research Papers that Mention the Interaction
“ Melatonin treatment increased total glutathione content and lowered the oxidized/reduced glutathione ratio , indicating a better redox status of the muscle.”
Melatonin improves muscle function of the dystrophic mdx5Cv mouse, a model for Duchenne muscular dystrophy“ Melatonin treatment decreased GSSG activity, thus elevating GSH/GSSG ratio, and also increased SOD and CAT activity without reaching statistical significance in the lesioned animals.”
“ Melatonin , by itself, significantly decreased GSSG content (p <.”
“Furthermore, melatonin prevented HFD-induced reduction in levels of GSH, and ratio of GSH/GSSG, and increase in GSSG in the hippocampus.”
Melatonin prevents memory impairment induced by high-fat diet: Role of oxidative stress“Moreover, melatonin cotreatment prevented an MPP+‐induced high ratio of GSSG and mitochondrial Drp1 upregulation.”
“In addition, melatonin enhanced the ratio of reduced to oxidized glutathione GSH/GSSG in sleep-deprived rats (P < 0.05) without affecting thiobarbituric acid reactive substance (TBARS) levels (P > 0.05).”
“ Melatonin counteracted the increased lipoperoxidation and nitric oxide, prevented decreased glutathione peroxidase and reductase activity, reduced the glutathione disulfide/glutathione (GSSG/GSH) ratio, and maintained the GSH pool.”
“Using isolated mitochondria, in a similar manner as cyclosporin A, melatonin (10−8–10−6 m) desensitized the PTP to Ca2+ and prevented t‐BHP‐induced mitochondrial swelling, pyridine nucleotide and glutathione oxidation.”
“Chronic treatment with melatonin counteracted the age-dependent LPO increase and GSH: GSSG ratio reduction in these mitochondria.”
“The increase in the muscle concentration of thiobarbituric acid reactive substances and in the oxidized/reduced glutathione ratio induced by exercise was partially prevented by melatonin.”
“GSH concentrations decreased and GSSG increased during ischemia-reperfusion and, again melatonin counteracted these changes.”
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