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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Co‐administration of melatonin and ghrelin more effectively prevented cisplatin‐induced follicle disruption.”
“In addition, melatonin and ghrelin co‐administration inhibited the cisplatin‐induced phosphorylation of PTEN and FOXO3a that induces cytoplasmic translocation of FOXO3a.”
“In this study, we found that the hormone ghrelin enhances the protective effect of melatonin against cisplatin‐induced ovarian failure in mouse model.”
“Simultaneous treatment with melatonin and ghrelin almost restored the number of primordial follicles and the corpus luteum in cisplatin‐treated ovaries, compared with single administration.”
Synergistic effect of melatonin and ghrelin in preventing cisplatin‐induced ovarian damage via regulation of FOXO3a phosphorylation and binding to the p27Kip1 promoter in primordial follicles“However, during the SDS season, GHRL reduced p31T-AA-NAT expression and the AA-NAT concentration ( < 0.01) and inhibited MEL secretion ( < 0.001), whereas during the LDS season, GHRL had no effect on MEL secretion or on the expression of the examined enzymes.”
“The experiments demonstrated that GHRL reduced MEL secretion ( < 0.01) during the SDS season.”
Effects of ghrelin on nocturnal melatonin secretion in sheep: An in vitro and in vivo approach.“The application of MLT increased both force and time-parameters of Ang II-and AVP-stimulated uterine contractions while treatment with GHR increased power characteristics and shortened contraction and relaxation of the smooth muscle process.”
“Addition of ghrelin and leptin to culture medium increased (P<0.01) melatonin concentration compared with ghrelin-treated culture and decreased melatonin concentration (P<0.01) compared with leptin-treated culture during SD.”
“Both doses of ghrelin reduced (P < 0.01) melatonin concentration during the SD season compared with control culture.”
“It is reported that pharmacological doses of melatonin decrease blood levels of ghrelin.”
“Plasma melatonin concentration correlated negatively with ghrelin , suggesting a possible role for melatonin in the regulation of ghrelin concentration.”
“Plasma ghrelin concentrations were significantly reduced by exogenous melatonin.”
“ Ghrelin alleviates sleep–wake disturbances by increasing the levels of melatonin , melanin-concentrating hormone.”
The Potential Roles of Ghrelin in Metabolic Syndrome and Secondary Symptoms of Alzheimer’s Disease
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