Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Melatonin and Ghrelin

supplement:

Melatonin

drug:

Ghrelin

Research Papers that Mention the Interaction

Co‐administration of melatonin and ghrelin more effectively prevented cisplatin‐induced follicle disruption.
In addition, melatonin and ghrelin co‐administration inhibited the cisplatin‐induced phosphorylation of PTEN and FOXO3a that induces cytoplasmic translocation of FOXO3a.
In this study, we found that the hormone ghrelin enhances the protective effect of melatonin against cisplatin‐induced ovarian failure in mouse model.
Simultaneous treatment with melatonin and ghrelin almost restored the number of primordial follicles and the corpus luteum in cisplatin‐treated ovaries, compared with single administration.
Journal of pineal research  •  2017  |  View Paper
However, during the SDS season, GHRL reduced p31T-AA-NAT expression and the AA-NAT concentration ( < 0.01) and inhibited MEL secretion ( < 0.001), whereas during the LDS season, GHRL had no effect on MEL secretion or on the expression of the examined enzymes.
The experiments demonstrated that GHRL reduced MEL secretion ( < 0.01) during the SDS season.
Journal of animal science  •  2017  |  View Paper
The application of MLT increased both force and time-parameters of Ang II-and AVP-stimulated uterine contractions while treatment with GHR increased power characteristics and shortened contraction and relaxation of the smooth muscle process.
Physiological research  •  2017  |  View Paper
Addition of ghrelin and leptin to culture medium increased (P<0.01) melatonin concentration compared with ghrelin-treated culture and decreased melatonin concentration (P<0.01) compared with leptin-treated culture during SD.
Both doses of ghrelin reduced (P < 0.01) melatonin concentration during the SD season compared with control culture.
Domestic animal endocrinology  •  2011  |  View Paper
It is reported that pharmacological doses of melatonin decrease blood levels of ghrelin.
Neuroscience Letters  •  2006  |  View Paper
Plasma melatonin concentration correlated negatively with ghrelin , suggesting a possible role for melatonin in the regulation of ghrelin concentration.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology  •  2005  |  View Paper
Plasma ghrelin concentrations were significantly reduced by exogenous melatonin.
Endocrine  •  2001  |  View Paper
Ghrelin alleviates sleep–wake disturbances by increasing the levels of melatonin , melanin-concentrating hormone.
Frontiers in Neuroscience  •  2020  |  View Paper