Possible Interaction: Melatonin and Gentamicin

“Moreover, melatonin may have properties protective against ototoxic drugs such as amikacin, gentamicin , or cancer therapeutic agents that are dose dependent.”

“Compared to a mixture of antioxidants which included tocopherol, ascorbate, glutathione and N-acetyl-cysteine, melatonin , also a documented antioxidant, was estimated to be up to 150 times more effective in limiting the cochlear side effects, evaluated using otoacoustic emission distortion products, of gentamicin , tobramycin and cisplatin.”

“ Melatonin has a dose dependent protective effect on the structural alterations of proximal tubules of the kidney induced by gentamicin.”

“These results suggest that melatonin protects against gentamicin ototoxicity by interfering with cytotoxic mechanisms.”

“The mean score of renal injury, highest in the rats receiving bile duct ligation and gentamicin injection, was significantly reduced with melatonin treatment.”

“On the other hand simultaneous melatonin administration protected kidney tissue against the oxidative damage and the nephrotoxic effect caused by GEN treatment.”

“An increased excretion of urinary N-acetyl-β-D-glucosaminidase, glucose, and protein by gentamicin was also prevented by melatonin.”

“ Melatonin reduced ROS production and caspase-3 activation in the gentamicin treated utricular hair cells.”

“Results The result of this study showed that gentamicin induced the loss of utricular hair cells, and this loss of hair cells was significantly attenuated by co-administration of melatonin.”