Possible Interaction: Melatonin and Gemcitabine

“Moreover, melatonin not only inhibited cell proliferation and invasion in a receptor‐independent manner, but also enhanced gemcitabine cytotoxicity at pharmacologic concentrations in these PDAC cells.”

“Our results showed that melatonin inhibited activities of NF‐κB by suppressing IκBα phosphorylation and decreased the expression of NF‐κB response genes in MiaPaCa‐2, AsPc‐1, Panc‐28 cells and gemcitabine resistance MiaPaCa‐2/GR cells.”

“Taken together, these results indicate that melatonin inhibits proliferation and invasion of PDAC cells and overcomes gemcitabine resistance of pancreatic tumors through NF‐κB inhibition.”

“Both melatonin and AFMK administered to PANC-1 in combination with gemcitabine inhibited the production of HSP70 and cIAP-2 as compared to the results obtained with gemcitabine alone.”

“These changes were accompanied by upregulation of Bax/Bcl-2 ratio and reduction of procaspases-… an increase in the formation of active caspase of PANC-1 cells with combination of gemcitabine … melatonin or AFMK led to enhanced cytotoxicity and resulted in … growth as compared to effects of gemcitabine alone.”