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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Melatonin
drug:
Gaba Agents
Research Papers that Mention the Interaction
“Several studies suggest that GABAergic mechanisms may be involved in the modulation of melatonin secretion.”
Preliminary Observations on the Suppression of Nocturnal Plasma Melatonin Levels by Short‐Term Administration of Diazepam in Humans“One of the possible mechanisms of action for melatonin in the brain is the interaction with the GABAergic system , as suggested by neurochemical and behavioral data.”
“In the present study, we showed that melatonin suppressed the activity of GABAergic neurons in the lateral hypothalamus, which has been reported to play a crucial role in maintaining wakefulness.”
“Overall, these results suggest that melatonin inhibits GABAergic neurons in the lateral hypothalamus via melatonin 1 receptor-dependent inhibition of the HCN channels, which is consistent with a decrease in wakefulness.”
Melatonin inhibits GABAergic neurons in the hypothalamus consistent with a reduction in wakefulness“Hence, our observation that melatonin has an enhancing effect on the GABAergic system may implicate a potential pathway for the neuroprotective effects of melatonin.”
“Melatonin thus appears to be an effective anticonvulsant, and melatonin ML(1) receptors, GABAergic and serotonergic mechanisms may play an important role in mediating the anticonvulsant activity of melatonin in electroshock seizures.”
“It is thought that the hypnotic activity of melatonin is mediated by GABAergic system.”
“These findings suggest that melatonin does have an inhibitory effect on ACh release, either by direct interaction with the cholinergic amacrine cell, or indirectly via GABAergic but not glutamatergic neurons.”
“Since the ability to allosterically inhibit TBPS binding is characteristic of GABA-positive ligands, these findings provide further evidence that the pharmacological effects of melatonin involve enhancement of central GABAergic activity.”
“These findings suggest that the central effects of melatonin involve modulation of GABAergic function.”
“However, other receptors such as alpha-adrenergic, D2-dopaminergic, GABAergic , benzodiazepinergic, and glutamatergic receptors and their agonists are also able to modulate the synthesis of melatonin , and this function depicts dramatic species variation.”
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