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International journal of molecular sciences • 2014 | View Paper
“Concerning the pituitary–gonad axis, we showed that melatonin treatment decreased both gonadotrophin β‐subunit (LHβ, FSHβ ) mRNA expression and reduced sexual steroid (11‐ketotestosterone, oestradiol) plasma levels.”
“ Melatonin suppresses luteinizing hormone-releasing hormone (LHRH)-stimulated release of luteinizing hormone (LH) and follicle-stimulating hormone from neonatal rat gonadotrophs.”
“As previously, melatonin (10-8 M) significantly suppressed LH and FSH release by all concentrations of LHRH.”
“The pineal indole melatonin suppresses the neonatal rat luteinizing hormone (LH) and follicle-stimulating hormone ( FSH ) responses to LH-releasing hormone (LHRH), as shown in previous studies from this laboratory.”