Possible Interaction: Melatonin and Fenclonine

“This paper shows that human lymphocyte-synthesized melatonin plays a crucial role modulating IL-2/IL-2 receptor system because when blocking melatonin biosynthesis by the tryptophan hydroxylase inhibitor, parachlorophenylalanine , both IL-2 and IL-2 receptor levels fell, restoring them by adding exogenous melatonin.”

“Treatment with a TRP hydroxylase inhibitor, para‐chlorophenylalanine , reduced basal melatonin release and inhibited the TRP‐induced melatonin stimulation.”

“ Melatonin levels were higher in PCPA treated mice in the brain, and in all GIT tissues, except the stomach.”

“In the dose‐response study, ≥0.5 mg/kg BW of melatonin induced a significant increase in hypothalamic 5‐HT content and ≥10 mg/kg BW of pCPA decreased it significantly.”

“ PCPA , known to inhibit serotonin synthesis and to lower the melatonin level in tissues, markedly delayed IOP recovery.”

“Combination of PCPA and melatonin significantly increased the immune parameters to the normal control level of both the age groups.”

“Melatonin injection at evening hours significantly increased the peripheral level of nighttime melatonin, while combined injection of PCPA and melatonin brought it to control level in both aged and young adult squirrels.”