Possible Interaction: Melatonin and Doxorubicin Hydrochloride

“Using doxorubicin-treated CHRF cells, we found that melatonin rescued G2/M cell cycle arrest and cell apoptosis induced by doxorubicin.”

“Expert opinion: Our findings clearly demonstrate that melatonin has a protective role in the prevention of chemotherapy-induced nephrotoxicity which may be caused by different chemotherapy agents such as cyclophosphamide, cisplatin, doxorubicin , methotrexate, oxaliplatin, etoposide, and daunorubicin.”

“Furthermore, melatonin in combination with doxorubicin or cisplatin, two compounds commonly used for the treatment of solid tumors, increased the sensitivity of RMS cells to apoptosis.”

“In terms of oncolytic activity, the combination of adriamycin and melatonin improved the antitumor activity of adriamycin, as indicated by an increase in the number of long-term survivors as well as decreases in body-weight losses resulting from adriamycin treatment.”

“ Melatonin attenuated adriamycin-induced body-weight loss, hemodynamic dysfunction, and the morphologic and biochemical alterations caused by adriamycin.”

“Rats that received a single intraperitoneal injection of 25 mg/kg adriamycin showed a mortality rate of 86%, which was reduced to 20% by melatonin treatment (10 mg/kg, SC for 6 days).”

“By functioning as a free radical scavenger and antioxidant, melatonin attenuates the toxicity of doxorubicin (and other chemotherapeutic drugs) thereby reducing the incidence and/or severity of cardiomyopathy (and nephropathy).”

“In these studies, when doxorubicin was given concurrently with melatonin the cardiac damage due to the anthracycline was substantially reduced.”

“This being the case, it is not surprising that melatonin also has been shown to reduce the toxicity of doxorubicin at the level of the heart [5–9].”

“Our results demonstrate that oxidative damage induced by the antitumor drug, adriamycin , can be reduced by low pharmacological doses of melatonin.”

“ Doxorubicin intracellular concentrations in P388/ADR cells are increased by melatonin , suggesting that melatonin might inhibit P‐glycoprotein‐mediated doxorubicin efflux from the cells.”

“ Melatonin has been reported to attenuate the oxidative damage caused by doxorubicin on kidney, brain, heart and bone marrow, whereas the in vivo antitumor effects of doxorubicin were not attenuated.”

“ Melatonin similarly causes minor effects on doxorubicin cytotoxicity either on the parental human cell lines or on their resistant sublines.”

“Moreover, there was a synergy in the antitumor effect when MLT was combined with DOX , especially in the nano-formulation form, which may be due to the down-regulation of X-linked Inhibitor of Apoptosis (XIAP), survivin, and human telomerase catalytic subunit (hTERT) (p < 0.0001).”

“We showed an enhanced apoptotic and anticancer activity of doxorubicin and melatonin combination chemotherapy on CC cell line than doxorubicin or melatonin treatments alone.”

“CONCLUSION The results of this systematic review indicated that co-administration of me atonin am eliorates the dox orubicin-induced ca rdiotoxicity.”

“The use of melatonin can lead to a decrease in the cardiotoxic effect induced by doxorubicin.”