Possible Interaction: Melatonin and Docetaxel

“ Docetaxel and vinorelbine increased the expression of VEGF-A , VEGF-B , VEGF-C , VEGFR-1 , VEGFR-3 , ANG1 and/or ANG-2 and melatonin inhibited these actions.”

“Our results confirm that melatonin blocks proangiogenic and potentiates antiangiogenic effects induced by docetaxel and vinorelbine enhancing their antitumor effectiveness.”

“…,melatonin prevented the … actions that docetaxel exerts on the expression of other factors related to angiogenesis like JAG1 , ANPEP , IGF-1 , CXCL6 , AKT1 , ERK1 , ERK2 , MMP14 and NOS3 and neutralized the stimulating actions of vinorelbine on the expression of FIGF , FGFR3 , CXCL6 , CCL2 , ERK1 , ERK2 , AKT1 , NOS3 and MMP14 .”

“ Melatonin potentiates the stimulatory effect of docetaxel and vinorelbine on differentiation and their inhibitory effects on aromatase activity and expression, by increasing the stimulatory effect on C/EBPα and PPARγ expression and the downregulation of antiadipogenic cytokines and COX expression.”

“Importantly, these effects were more potent when melatonin was added prior to docetaxel.”

“In this study, we demonstrated that melatonin enhanced the anti-proliferative and apoptotic responses to low doses of docetaxel in breast cancer cells.”

“ Melatonin further stimulated the expression of the pro-apoptotic BAD and BAX genes, and enhanced the inhibition of the anti-apoptotic gene BCL-2 induced by docetaxel.”

“Specifically, docetaxel downregulated TP53, cyclin-dependent kinase inhibitor 1A (CDKN1A) and cadherin 13 (CDH13), and upregulated mucin 1 (MUC1), GATA binding protein 3 (GATA3) and c-MYC, whereas melatonin counteracted these effects.”

“Treatment with 1 µM docetaxel (equivalent to the therapeutic dosage) induced changes in gene expression profiles and melatonin modulated these changes.”

“In addition to cytokines such as hrTNF‐alpha and TRAIL, chemotherapeutic compounds, including doxorubicin, docetaxel , or etoposide, were employed in combination with melatonin to promote cell death.”

“Supplementation of AT administered at 5:00 p.m. with MT improved the tumor response.”