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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Disruption of circadian time structure and suppression of circadian nocturnal melatonin MLT ) production by exposure to dim light at night (dLAN), as occurs with night shift work and/or disturbed sleep‐wake cycles, is associated with a significantly increased risk of breast cancer and resistance to tamoxifen and doxorubicin.”
Epigenetic inhibition of the tumor suppressor ARHI by light at night‐induced circadian melatonin disruption mediates STAT3‐driven paclitaxel resistance in breast cancer“Thus, we hypothesized that dim light at night, by blocking the night-time rise of melatonin levels, may promote tamoxifen resistance,” says Steven Hill, who was involved in the new study.”
“ Dim light at night (LAN)-induced melatonin suppression disrupts this circadian-regulated host/cancer balance among several important cancer preventative signaling mechanisms, leading to hyperglycemia and hyperinsulinemia in the host and runaway aerobic glycolysis, lipid signaling and proliferative activity in the tumor.”
“There were differential associations between dim light melatonin onset and cognition between the two groups, with earlier dim light melatonin onset being associated with poorer memory performance in MCI patients.”
“Results showed that the very dim light level, compared to the typical room light level, prior to the light exposure at night caused a substantially greater phase shift of the melatonin rhythm and substantially greater acute melatonin suppression.”
“There was an advance in dim light melatonin onset of 44.4 +/- 67.9 minutes in melatonin and a delay of 12.8 +/- 60.0 minutes in placebo (p < .0001).”
“The aim of the following two-part study was to test the hypothesis that dim light adaptation will dampen the subsequent suppression of melatonin by monochromatic light in healthy human subjects.”
“There is evidence that the early morning transition from dim to bright light not only suppresses melatonin secretion; it also induces a marked elevation of cortisol levels (7).”
“The early morning transition from dim to bright light suppressed melatonin secretion, induced an immediate, greater than 50% elevation of cortisol levels, and limited the deterioration of alertness normally associated with overnight sleep deprivation.”
“However, the effect of gender on the melatonin suppression by dim and bright light is still controversial.”
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