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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Melatonin
drug:
Dihydrotestosterone
Research Papers that Mention the Interaction
“ Melatonin also caused nuclear exclusion of the AR in the presence of DHT.”
Nuclear exclusion of the androgen receptor by melatonin“Furthermore, melatonin inhibited H‐thymidine incorporation into LNCaP cells and attenuated 5α‐dihydrotestosterone (DHT) or 17β‐estradiol (E2)‐induced stimulation of LNCaP cell proliferation at physiological and pharmacological concentrations.”
“In cells grown with DHT, melatonin responses were extenuated.”
“These data indicate that 1) DHT and E2 enhance prostate epithelial cells growth, but reduce cell growth when combined; 2) DHT extenuates the inhibitory effects of melatonin on epithelial cell growth; and 3) E2 acts to inactivate melatonin receptors and consequently responses in human epithelial benign prostatic hyperplasia cells.”
“It was concluded that treatment with DHT prevents the depressive action of melatonin on testicular function by inducing the synthesis of alpha 2u-globulin.”
Effect of dihydrotestosterone on serum concentrations of alpha 2u-globulin and on spermatogenesis in melatonin-treated rats.“ Melatonin content of the glands dropped 20 days after treatment with testosterone and 10 days after the administration of 5α-dihydrotestosterone.”
“ Melatonin implants in pinealectomized males led to an increase in both testosterone and DHT levels, accompanied by a decrease in sexual organ weights.”
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