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Discover Supplement-Drug Interactions

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Last Updated: 5 years ago

Possible Interaction: Melatonin and Cpt-11

supplement:

Melatonin

drug:

Cpt-11

Research Papers that Mention the Interaction

Moreover, a stable disease (SD) was obtained in 5 out of 16 patients treated with CPT-11 alone and in 7 out of 14 patients treated with CPT-11 plus MLT.
The only important toxicity was diarrhoea grade 3-4, which occurred in 6 out of 16 patients treated with CPT-11 alone and in 4 out of 14 patients treated with CPT-11 plus MLT , which required a 50% dose reduction.
This preliminary study shows that the efficacy of weekly low-dose CPT-11 in pretreated metastatic colorectal cancer patients may be enhanced by a concomitant daily administration of the pineal hormone MLT , according to the results previously reported for other chemotherapeutic agents.
Anticancer research  •  2003  |  View Paper