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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Melatonin and Corticorelin Ovine

Research Papers that Mention the Interaction

Incubation of primary cultures for 2 h with 100 nmol/l of melatonin , serotonin or 5-methoxytryptamine significantly increased the beta-end release in response to 20 nmol/l of ovine corticotropin-releasing factor (oCRF).
Simultaneous superfusion with melatonin (1 mumol/l) or serotonin (1 mumol/l) significantly increased the effect of oCRF pulses on beta-end release.
We conclude that melatonin and serotonin are able to act directly on anterior pituitary cells to potentiate the effect of oCRF on beta-end release.
Neuroendocrinology  •  1985  |  View Paper