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Last Updated: 3 years ago

Possible Interaction: Melatonin and Colforsin

supplement:

Melatonin

Research Papers that Mention the Interaction

The inhibitory effects of melatonin were reversible and preventable with either melatonin receptor antagonist S20928, pertussis toxin, forskolin , or 8‐Br‐cAMP.
Journal of pineal research  •  2009  |  View Paper
Acute melatonin treatment (6 h) in the presence of either forskolin or 3-isobutyl-1-methylxanthine caused a significant decrease in insulin release and induced significant downregulation of calcium/calmodulin-dependent kinase IV and calcium/calmodulin-dependent kinase 2d transcripts in INS-1 batch cultures.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme  •  2009  |  View Paper
Pretreatment of either MT(1)- or MT(2)-CHO cells with melatonin (1 microM for 5hr) resulted in: (a) a complete loss of melatonin-mediated stimulation of PI hydrolysis, and (b) an attenuation of melatonin (1nM)-mediated inhibition of forskolin-induced cAMP accumulation by approximately 20-40%.
Biochemical pharmacology  •  2002  |  View Paper
Forskolin , an adenylate cyclase activator, prevented the protective effects of melatonin ; inhibitors of protein kinase C and mitogen‐associated protein kinase had no detectable effect.
Annals of neurology  •  2002  |  View Paper
This inhibitory effect of melatonin is reversible with either pertussis toxin, forskolin or cAMP.
Neurosignals  •  1999  |  View Paper
In Chinese hamster ovary cells expressing human mt1 or MT2 receptors, both melatonin and GR196429 dose-dependently inhibited forskolin-stimulated cAMP accumulation.
The Journal of pharmacology and experimental therapeutics  •  1998  |  View Paper
Melatonin (1 microM) decreased the forskolin (10 microM) stimulated cAMP level by 50%.
Endocrinology  •  1997  |  View Paper
Cells pretreated with melatonin revealed a persistent inhibition (approximately 20%) of forskolin-induced cAMP formation that was not reversed by extensive washes (up to 1 hr) or when luzindole (1 microM) was added together with melatonin during pretreatment.
Low concentrations of melatonin (0.01 fM-1 PM) inhibited forskolin (100 microM)-stimulated cAMP formation with an IC50 of 0.1 +/- 0.05 PM (four experiments) and a maximal inhibitory effect (26%) at 1 PM.
Melatonin (0.1 fM-1 nM) inhibited forskolin-induced cAMP formation in a concentration-dependent and biphasic manner.
melatonin (1 … forskolin-induced cAMP formation with an IC50 of 64 +/- 1.8 PM (four experiments) and a maximal inhibition (74%) at 1 nM. Luzindole (1 microM), … antagonist, antagonized the effect of melatonin at the higher concentrations only (IC50 = 1.5 +/- 0.22 nM, pKB = -7.3; three experiments).
Molecular pharmacology  •  1996  |  View Paper
Melatonin (10 nm) was consistently found to be a highly potent inhibitor of the activation of MAPK induced by forskolin ; in contrast, melatonin did not inhibit the activation of MAPK induced by IGF-1.(ABSTRACT TRUNCATED AT 400 WORDS)
Endocrinology  •  1996  |  View Paper
Melatonin and iodomelatonin caused dose-dependent reductions in forskolin-stimulated cAMP production with half-maximal values of 2.4 x 10(-9)M and 3.28 x 10(-9)M, respectively.
Investigative ophthalmology & visual science  •  1995  |  View Paper
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