Possible Interaction: Melatonin and Calcium Supplement

“On the other hand, we verified that melatonin reduced the formation of inflammasome multiprotein complexes by modulating calcium ions in macrophages using a live cell station, and melatonin decreased inositol triphosphate and increased cAMP.”

“Several studies have recently shown that melatonin can modify calcium (Ca(2+)) in diabetic animals, and Ca(2+) has been reported to be involved in glucose homeostasis.”

“Exogenous melatonin stimulated increases in intracellular calcium ([Ca2+]i) in dissociated human islet cells, and stimulated glucagon secretion from perifused human islets.”

“ Melatonin induced release of calcium from intracellular stores and also influx of extracellular calcium in isolated duodenal enterocytes.”

“In addition melatonin can probably influence the levels of intracellular calcium in cardiomyocytes.”

“Coordination between either serotonin or melatonin and calcium was not favoured.”

“Treatment did not significantly affect BMD at other sites or levels of bone turnover markers; however, 24‐hr urinary calcium was decreased in response to melatonin by 12.2% (P = 0.02).”

“ Melatonin markedly reduced NARP-augmented H/RO-induced mROS formation and therefore significantly reduced mROS-mediated depolarization of ΔΨm and accumulation of mCa2+ , stabilized cardiolipin, and then improved mitochondrial movement and cell survival.”

“Here we show that, melatonin at high concentration is capable of significantly raising platelet intracellular calcium even in the absence of an agonist.”

“Thus, our data suggest that melatonin evoked the elevation of platelet intracellular calcium through depletion of mitochondrial Ca2+ stores and store‐operated calcium entry (SOCE), while the action was independent of the PLC‐IP3 axis.”

“ Melatonin has been reported as important anti-apoptotic agent in various tissues by reducing cell calcium uptake, modulating expression of anti-oxidants and decreasing pro-apoptotic protein, such as Bax.”