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Last Updated: 3 years ago
supplement:
Melatonin
Research Papers that Mention the Interaction
“ Melatonin also reversed ER stress induced by BDL.”
Melatonin Alleviates Liver Apoptosis in Bile Duct Ligation Young Rats“In addition, melatonin pre-treatment also increased the phosphorylation of Akt, GSK-3β, ERK1/2 and STAT3 and reduced PERK-eIF2α-ATF4-mediated ER stress.”
“The results demonstrate that melatonin inhibited peritoneal metastasis in vivo and activated ER stress in Cignal ERSE Reporter Assay, organelle structure in transmission electron microscopy images, calpain activity, and protein biomarkers like p‐elf2α.”
“In conclusion, this study provides new insights into the mechanisms by which melatonin confers its protective actions during ER stress.”
“Under ER stress, melatonin significantly suppressed the induction of immunoglobulin heavy‐chain‐binding protein (BiP) and activation of inositol‐requiring enzyme 1α (IRE1α), and their downstream target, alternative splicing of X‐box binding protein 1(XBP1).”
“Upon treatment of cells with melatonin , increases in the expression of major markers of ER stress , namely BIP, phospho-eIF2α and ATF-4, were detected.”
Melatonin Induces Apoptosis and Modulates Cyclin Expression and MAPK Phosphorylation in Pancreatic Stellate Cells Subjected to Hypoxia“These results demonstrate that high stress status may have impacted melatonin production and secretion by the pineal organ.”
“Taken together, the results of the present study showed that melatonin may attenuate the inflammatory response by inhibiting the activation of ERS in RAW264.7 macrophages.”
“Moreover, we demonstrated that DBP treatment led to the generation of reactive oxygen species (ROS) and that the inhibition of ROS by melatonin abrogated both ER stress and autophagy.”
“Cell viability was significantly decreased after treatment with melatonin combined with ER stress from thapsigargin or tunicamycin compared to no treatment or treatment with melatonin only.”
“Combined melatonin and ER stress also significantly reduced expression of p85β, p-Akt (Ser473, Thr308), and p-mTOR (Ser2448, Ser2481) compared to treatment with melatonin only.”
“Results indicate that, in addition to its antioxidant and antiapoptotic effects, and the suppression of ER stress, melatonin induces a decrease in autophagy associated with RHDV infection and inhibits RHDV RNA replication.”
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