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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Melatonin
supplement:
Asymmetric Dimethylarginine
Research Papers that Mention the Interaction
“Next, melatonin decreased renal ADMA concentrations, increased renal arginine-to-ADMA ratio, and restored NO production in L-NAME-treated young SHRs.”
Renoprotective effects of melatonin in young spontaneously hypertensive rats with L-NAME.“Additionally, melatonin increased protein levels of mammalian targets of rapamycin (mTOR), decreased plasma asymmetric dimethylarginine ( ADMA ) and symmetric dimethylarginine levels, and increased the l-arginine-to-ADMA ratio.”
Maternal Melatonin Therapy Attenuated Maternal High-Fructose Combined with Post-Weaning High-Salt Diets-Induced Hypertension in Adult Male Rat Offspring“ Melatonin administration prevented an increase in the ADMA levels in the plasma, prefrontal cortex, and dorsal hippocampus, and prevented spatial deficits in BDL rats.”
“ Melatonin prevented ADMA increases in the liver mainly by regulating DDAH-1 and -2.”
“ Melatonin decreased plasma ADMA level and restored plasma AAR.”
“In conclusion, melatonin therapy decreased mortality and prevented kidney injury induced by BDL via reduction of ADMA (by increasing DDAH activity) and oxidative stress.”
“We hypothesized that asymmetric dimethylarginine (ADMA) is involved in BDL‐induced oxidative stress and kidney injury, which can be prevented by melatonin.”
“ Melatonin therapy also partially prevented the increases in ADMA in male CKD rats.”
Melatonin Prevents Chronic Kidney Disease-Induced Hypertension in Young Rat Treated with Adenine: Implications of Gut Microbiota-Derived Metabolites
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