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Last Updated: 2 years ago

Possible Interaction: Melatonin and Asymmetric Dimethylarginine

Research Papers that Mention the Interaction

Next, melatonin decreased renal ADMA concentrations, increased renal arginine-to-ADMA ratio, and restored NO production in L-NAME-treated young SHRs.
Pediatrics and neonatology  •  2014  |  View Paper
Additionally, melatonin increased protein levels of mammalian targets of rapamycin (mTOR), decreased plasma asymmetric dimethylarginine ( ADMA ) and symmetric dimethylarginine levels, and increased the l-arginine-to-ADMA ratio.
Molecules  •  2018  |  View Paper
Melatonin administration prevented an increase in the ADMA levels in the plasma, prefrontal cortex, and dorsal hippocampus, and prevented spatial deficits in BDL rats.
Neuroreport  •  2018  |  View Paper
Melatonin prevented ADMA increases in the liver mainly by regulating DDAH-1 and -2.
Free radical biology & medicine  •  2010  |  View Paper
Melatonin decreased plasma ADMA level and restored plasma AAR.
Journal of pineal research  •  2010  |  View Paper
In conclusion, melatonin therapy decreased mortality and prevented kidney injury induced by BDL via reduction of ADMA (by increasing DDAH activity) and oxidative stress.
We hypothesized that asymmetric dimethylarginine (ADMA) is involved in BDL‐induced oxidative stress and kidney injury, which can be prevented by melatonin.
Journal of pineal research  •  2010  |  View Paper
Melatonin therapy also partially prevented the increases in ADMA in male CKD rats.
Antioxidants  •  2021  |  View Paper