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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“At doses of 10–40 mg/kg, melatonin counteracted the PTZ‐induced glutamine increase and reduced both glutamate and asparatate levels in the studied areas, with minor changes in GABA and glycine content.”
Changes in brain amino acids and nitric oxide after melatonin administration in rats with pentylenetetrazole‐induced seizures“ Melatonin can significantly reduce the increase of aspartate and glutamate, to 55.1% and 57.0% of the hypoxic group.”
“It was found that L-aspartate inhibits norepinephrine-stimulated melatonin production as well as serotonin N-acetyltransferase activity reversibly and dose-dependently, the concentrations required for 50% inhibition being 150 and 175 microM, respectively.”
“These results suggest that pinealocytes use L-aspartate , as well as L-glutamate, as a negative regulator for melatonin production.”
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