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Last Updated: 2 years ago

Possible Interaction: Melatonin and Aspartate

supplement:

Melatonin

Research Papers that Mention the Interaction

At doses of 10–40 mg/kg, melatonin counteracted the PTZ‐induced glutamine increase and reduced both glutamate and asparatate levels in the studied areas, with minor changes in GABA and glycine content.
Journal of pineal research  •  2003  |  View Paper
Melatonin can significantly reduce the increase of aspartate and glutamate, to 55.1% and 57.0% of the hypoxic group.
Sheng li xue bao : [Acta physiologica Sinica]  •  1999  |  View Paper
It was found that L-aspartate inhibits norepinephrine-stimulated melatonin production as well as serotonin N-acetyltransferase activity reversibly and dose-dependently, the concentrations required for 50% inhibition being 150 and 175 microM, respectively.
These results suggest that pinealocytes use L-aspartate , as well as L-glutamate, as a negative regulator for melatonin production.
Neuroscience Letters  •  1997  |  View Paper