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Last Updated: 2 years ago

Possible Interaction: Melatonin and Agomelatine

supplement:

Melatonin

Research Papers that Mention the Interaction

By way of behavioral studies in rodents, it has been shown that administration of agomelatine can mimic the action of melatonin in the synchronization of circadian rhythm patterns.
Medecine sciences : M/S  •  2005  |  View Paper
This is of particular interest in light of the “synergistic” melatonin agonist/5-HT2C antagonist profile of the novel antidepressant agomelatine.
The Journal of Biological Chemistry  •  2015  |  View Paper
Melatonin in combination with agomelatine has been recently reported to reduce intraocular pressure (IOP) with higher efficacy than each compound alone.
International journal of molecular sciences  •  2020  |  View Paper
The antidepressant agomelatine had a similar effect than melatonin when applied alone but blocked the melatonin‐promoted Gq activation due to its 5‐HT2C antagonistic component.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology  •  2020  |  View Paper
Daily administration of melatonin, agomelatine or ramelteon delays the occurrence of severe clinical outcome with improvement of survival, especially with high melatonin dose.
Journal of pineal research  •  2021  |  View Paper
Nanomicellar formulations of melatonin and agomelatine , either alone or in combination, had lowering effects that did not depend on their concentration or their combination, which, however, resulted in an increased duration of the hypotonizing effect.
Diagnostics  •  2020  |  View Paper
Agomelatine is a new antidepressant that raises serotonin level and enhances melatonin production.
The primary care companion for CNS disorders  •  2011  |  View Paper