Possible Interaction: Melatonin and Agomelatine

“By way of behavioral studies in rodents, it has been shown that administration of agomelatine can mimic the action of melatonin in the synchronization of circadian rhythm patterns.”

“This is of particular interest in light of the “synergistic” melatonin agonist/5-HT2C antagonist profile of the novel antidepressant agomelatine.”

“ Melatonin in combination with agomelatine has been recently reported to reduce intraocular pressure (IOP) with higher efficacy than each compound alone.”

“The antidepressant agomelatine had a similar effect than melatonin when applied alone but blocked the melatonin‐promoted Gq activation due to its 5‐HT2C antagonistic component.”

“Daily administration of melatonin, agomelatine or ramelteon delays the occurrence of severe clinical outcome with improvement of survival, especially with high melatonin dose.”

“Nanomicellar formulations of melatonin and agomelatine , either alone or in combination, had lowering effects that did not depend on their concentration or their combination, which, however, resulted in an increased duration of the hypotonizing effect.”

“ Agomelatine is a new antidepressant that raises serotonin level and enhances melatonin production.”