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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Melatonin
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“ Melatonin treatment prevented the alteration in 24-hour rhythms of serum ACTH , prolactin and luteinizing hormone in rats injected with FCA.”
Circadian Disorganization in Experimental Arthritis“An interaction between melatonin and adrenocorticotropin (ACTH) seems to occur in humans and both hormones respond to beta‐adrenergic stimulation.”
“Collectively, the results showed that melatonin facilitated aldosterone production induced by ACTH and activin via the cAMP-PKA pathway.”
“ Melatonin has been reported to suppress adrenocorticotropin (ACTH) secretion in the anterior pituitary and cortisol production in the adrenal by different mechanisms.”
“In nonhuman primates and rodents, melatonin acting directly on the adrenal gland, inhibits glucocorticoid response to ACTH.”
“ Melatonin inhibited these ACTH effects.”
“Our study demonstrates, for the first time, direct inhibitory effects of melatonin upon several ACTH responses in the human adrenal gland.”
“ Melatonin ingestion reduced the cortisol response to ACTH from 14.6 +/- 1.45 microg/dl at 60 min in the placebo group to 10.8 +/- 1.2 microg/dl in the melatonin group (p < 0.01 mixed model test).”
“Furthermore, melatonin has been described as performing an antiaggregating activity, and ACTH and vitamin E have been described as increasing melatonin effects.”
“Blood plasma concentration of ACTH was diminished significantly by 10(-7) M melatonin in DMSO-infused, but not in luzindole- or 4-P-PDOT-injected rats, however, it remained inactive in modifying the corticosterone blood plasma concentrations in any of the studied subgroups.”
The influence od melatonin receptors antagonists, luzindole and 4-phenyl-2-propionamidotetralin (4-P-PDOT), on melatonin-dependent vasopressin and adrenocorticotropic hormone (ACTH) release from the rat hypothalamo-hypophysial system. In vitro and in vivo studies.“Significant inhibitory effects of MLT (1 mg/kg) were observed on the plasma concentrations of CRH, ACTH , and corticosterone of the HPA axis.”
“We found that melatonin directly inhibits the response to noradrenaline in the MCA and BAT, and also inhibits the response to ACTH in the adrenal gland.”
“The elevated levels of melatonin during winter months might inhibit the synthesis of ACTH , probably when affecting some secretagogue of this pituitary hormone.”
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