Possible Interaction: Melatonin and Adrenergic Antagonists

“However, at 15 nM it acts as an α-adrenergic receptor antagonist , enhancing the melatonin effect.”

“These data suggest that mM concentrations of the pineal hormone are able to stimulate 5‐HT release from the pinealocyte, while mM concentrations of melatonin increase extracellular 5‐HT by inhibiting its reuptake in the adrenergic nerve endings.”